Evaluation of DNA-binding, cleavage, BSA interaction of Zn-hydroxy flavone complex | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.


Evaluation of DNA-binding, cleavage, BSA interaction of Zn-hydroxy flavone complex

Author(s): S. Iyyam Pillai, K. Vijayaraghavan and S. Subramanian*

Zinc is an essential trace element vital for many physiological functions. In the present study, DNA binding and cleavage activities of a novel Zn-flavonol complex was investigated. The interaction of the complex with CT-DNA has been explored by absorption, emission, viscosity and circular dichoric measurements. The complex exhibited hypochromicity in absorption and an increase in specific viscosity, which revealed that the complex bound to CTDNA through an intercalation mode. The calculated intrinsic binding constant (Kb) was found to be 6.2 x 104 M-1. The data revealed that the complex facilitates the cleavage of super coiled pBR322 DNA (Form I) to the open circular form (Form II) and linear form (Form III) via a hydrolytic pathway. Further, the synthesized complexes altered the intrinsic fluorescence of bovine serum albumin (BSA) through a static quenching with the binding constants (Ksv) of 1.6 x 105 M-1 with a number of binding sites of 0.98.


Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Google Scholar citation report
Citations : 25868

Der Pharma Chemica received 25868 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry