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Evaluation of in vitro antioxidant activity of benzophenone-pyridine analogues | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Evaluation of in vitro antioxidant activity of benzophenone-pyridine analogues

Author(s): Yasser Hussein Issa Mohammed, Noor Fathima Khanum, Mohammed Al-Ghorbani, Zabiulla and Shaukath Ara Khanum

A series of synthesized benzophenones possessing pyridine nucleus 8a–l were evaluated for antioxidant activity by in vitro studies through different in vitro models such as DPPH, nitric oxide and hydrogen peroxide free radicalscavenging activity. The antioxidant activity result shows that compound 8k with hydroxy and methyl groups exhibited highest activity. Compounds 8l with amino and methyl groups has shown second highest activity. Further, compounds 8b with fluoro and hydroxy groups, 8e with chloro and hydroxy groups and 8h with iodo and hydroxy groups also exhibited activity next to compounds 8k and 8l..


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