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Evaluation of miscellaneous heat shock protein (Hsp90) inhibitors using different methodologies | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Evaluation of miscellaneous heat shock protein (Hsp90) inhibitors using different methodologies

Author(s): Mahmoud A. Al-Sha’er

In this review, 100 diverse chemical derivatives were either designed, synthesized or naturally screened and tested as Hsp90 inhibitors, miscellaneous derivatives were synthesized that represent different scaffolds. Anti-Hsp90 activities of these compounds were examined and diverse activities were observed. Although Hsp90 inhibition had activities against cancerous cell line, there is no Hsp90 inhibitor as anticancer FDA approved drug yet, however some clinically investigated Hsp90 inhibitors are in phase I and phase II. Hsp90 inhibitors could act as a new strategy for treatment of cancer as a chronic disease rather than using typically aggressive chemotherapeutic agents.


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