Throughout history, natural products have afforded a rich source of compounds that have found many applications in the fields of medicine, pharmacy and biology. Within the sphere of immunomodulation, a number of important new commercialized drugs have been obtained from natural sources, by structural modification of natural compounds or by the synthesis of new compounds, designed following a natural compound as model. To search for improved immunomodulators, 1-Phenylnaphthalene and Pericarbonyl lactone lignans and their synthetic derivatives were tested for the immunomodulatory activity by the assay of Spleen cell proliferation. The investigation found that the naturally occurring and related synthetic organic compounds with 1-Phenylnaphthalene and Pericarbonyl lactone systems were potent in producing immune stimulation. In HIV treatment, they can assist the immune system in driving out the HIV virus and are expected to lower the incidence of opportunistic infections in several immunodeficiencies.
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