Background: A breakdown in the protective function of skin with a loss of framework of epithelium is defined as wound. A wound can range from simple to complex pathological process and remained as clinical challenge. Complications of wound cause morbidity and mortality. Materials and Methods: The present study was carried out using Aqueous Polyherbal extract Preparation (APHP) (250 mg/kg and 500 mg/kg) of Indigofera zollingeriana, Dillenia indica, Strobilanthes barbatus, Mimusops elengi. Povidone iodine was taken as standard. Wound healing activity was assessed using excision and incision models. Antioxidant assays were performed for SOD and catalase. Western blotting for MMP-2 and MMP-9 and histopathology were performed. Results: APHP had showed a significant dose dependent effect on surface area of wound, duration of epitheliazation, hydroxyproline content, dry weight of tissue and tensile strength (p<0.05). APHP in a dose dependent manner had significantly increased the levels of SOD and CAT (p<0.05).MMP-2 and MMP-9 expressions were significantly increased in a dose dependent manner (p<0.05). Histopathological studies had also revealed that APHP is having wound healing potential in a dose dependent manner.
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