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Extractive spectrophotometric methods for the determination of docetaxel in pure and pharmaceutical formulations | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Extractive spectrophotometric methods for the determination of docetaxel in pure and pharmaceutical formulations

Author(s): T. Naganjaneyulu, T. Archana Devi, C.Papa Rao, S. V. Venkat Rao and C. Rambabu

Two sensitive extractive spectrophometric methods have been developed for the estimation of Docetaxel in pure and pharmaceutical dosage forms. The developed methods are based on the formation of colored chloroform extractible ion-association complex of the drug with Alizarin red-s [ARS] and Tropaeolin ooo[TPooo]. The extracted complexes showed absorbance maxima at 424 and 430 nm respectively for these methods. Beer’s law is obeyed in the concentration ranges between 8-40 μg/ml for the two methods. The effective concentration of dyes, pH and optimum conditions have been established for these methods. The methods are applied for the determination of drugs in commercial tablets and results of analysis were validated statistically through recovery studies.


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