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Facile enantioselective synthesis of (S)-Rivastigmine and (+)-NPS-R- 568 a calcimimetic agent | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Facile enantioselective synthesis of (S)-Rivastigmine and (+)-NPS-R- 568 a calcimimetic agent

Author(s): Veera Reddy. Arava*, Laxminarasimhulu. Gorentla and P. K. Dubey

A practical and convenient procedure for the synthesis of enantioselective (S)-Rivastigmine and (+)-NPS-R-568 a potent calcimimetic agent is accomplished by the treatment of (S) and (R)-tertbutanesulfinamides respectively with 3-methoxyacetophenone. This protocol provides high yield and excellent enantiomeric excess in short step synthesis.


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