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First total synthesis and biological screening of c
yclic tetrapeptides from
Author(s): Nirmala V. Shinde
, Avinash S. Dhake
and Kishan P. Haval
Synthesis and cytotoxic, antimicrobial screening of cyclic tetratapeptides from onychocolascleroticais described. Structureof synthesized compounds were confirmed by detailed spectral analysis including FTIR, 1 H NMR, 13 C NMR, MSand elemental analysis. The spectral data sh owed that the synthesized compounds areidentical to the naturally occurring compound.The results of screeni ngindicated that synthesized compounds possessvery good antimicrobial activity against Gram positive bacter ia, moderate antifungal activity against pathogenic fungi and poor cytotoxic activity.