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First total synthesis and biological screening of c yclic tetrapeptides from onychocola sclerotica | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

First total synthesis and biological screening of c yclic tetrapeptides from onychocola sclerotica

Author(s): Nirmala V. Shinde 1,2* , Avinash S. Dhake 2 and Kishan P. Haval 3

Synthesis and cytotoxic, antimicrobial screening of cyclic tetratapeptides from onychocolascleroticais described. Structureof synthesized compounds were confirmed by detailed spectral analysis including FTIR, 1 H NMR, 13 C NMR, MSand elemental analysis. The spectral data sh owed that the synthesized compounds areidentical to the naturally occurring compound.The results of screeni ngindicated that synthesized compounds possessvery good antimicrobial activity against Gram positive bacter ia, moderate antifungal activity against pathogenic fungi and poor cytotoxic activity.


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