Formation of solid dispersion of PEG-1000 with phenacetin according to differential scanning calorimetry | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X


süperbetin giriş

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

agariookey oyna istanbul okey


Formation of solid dispersion of PEG-1000 with phenacetin according to differential scanning calorimetry

Author(s): Alexander V. Gerasimov*, Marat A. Ziganshin, Valery V. Gorbatchuk and Liana S. Usmanova

The formation of solid dispersions is one of the methods for drug hydrophilization. The data obtained by low temperature differential scanning calorimetry (DSC) has shown an opportunity to formation of solid dispersions of a hydrophobic drug – phenacetin with a biocompatible polymer – polyethylene glycol. It was established that in case of polymer:phenacetin 5-10:1 ratios the crystalline phase of the drug is not formed, while in case of 1-4:1 ratios the pharmacological component shows features of a separate phase and does not form a solid dispersion. The observed exo-effects on DSC curves of the mixtures of polymer:phenacetin with ratios of 1-2:1 and 7-10:1 are related to low-temperature crystallization of polymer. Optimal polymer:drug ratio is 5-6:1. At these ratios phenacetin completely dissolved in the polyethylene glycol phase and the quasi-stationary state caused amorphous part in solid dispersion is not observed. This together with absence of polymer plasticization by phenacetin may facilitate the release of the drug from the composite in hydrophilic media. The melting temperature of solid dispersions does not exceed 35.2 °Ð¡ allowing their use as capsular drugs, ointments and suppositories.


Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Recommended Conferences
Google Scholar citation report
Citations : 11575

Der Pharma Chemica received 11575 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons

rokettube brazzers

Turkish dental care is known to be affordable compared to other countries. If you want an affordible dentist Turkey, check out periodonta. It is heavily recommended for dental patients visiting Turkey