Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Formulation and Characterization of Orlistat Fast Dissolving Tablets
Author(s): N. Krishna Veni*The present study was aimed at the formulation of immediate release Orlistat. The therapy with these drugs offers a good quality of life for patients who are suffering from obesity. The key advantage of this drug is its specificity of action, high safety and excellent efficacy.
Aim of the study: The oral drug delivery has been famous for many years because the most generally utilized route of administration among all the routes that are explored for the general delivery of drugs via varied pharmaceutical product of various indefinite quantity forms. The reasons that the oral route achieved such quality could also be partially attributed to its simple administration likewise because the ancient belief that by oral administration the drug is as well absorbed as the foodstuffs that are ingested daily. Pharmaceutical product designed for oral delivery and presently on the market on the prescription and over the counter markets are principally the immediate-release kind, which are designed for immediate release of drug for rapid absorption. These systems guarantee complete solubilisation of the pill through surface erosion resulting in elimination of lag time for disintegration thereby offering faster absorption and rapid onset of action. Despite increasing interest in controlled–release drug delivery systems, the most common tablets are those intended to be swallowed whole and to disintegrate and release their medicaments rapidly in the gastro intestinal tract. In more recent years, increasing attention has been paid to formulate immediate release dosage forms.
Objective of study: The main objective of this work is to design and development of Orlistat fast dissolving tablets by direct compression technique. It is the best method to decrease the wetting and disintegration time and to increase the patient compliance. Immediate breaking of the tablet takes place when it is placed into the mouth. Thus immediate release formulation shows the good results.
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