In the present Clobetosole Propionate (CP) Solid Lipid Nanoparticles (SLN) have been formulated, to increase drug stability and to improve skin retention properties. The nanoparticles were prepared using lipid extrusion method followed by high pressure homogenization at speed of 15000 rpm for 30 min. Six formulations were prepared using variable ratio of the lipids, keeping rpm, time, concentration of surfactants, and active ingredient constant. Formulations were prepared using bees wax, carnauba wax, cetyl alcohol as oil phase, lecithin soya and tween 20 as emulsifying agent. The SLNs were characterized for visual appearance, drug content, particle size analysis, zeta potential, Scanning Electron Microscopy (SEM), Differential Scanning Calorimetry (DSC). Six formulations were subjected to in vitro release characteristics. The formulation F6 with highest drug content and encapsulation efficiency was incorporated into carbopol gel base. The particle size was ranged between 46.33-301.2 nm and zeta potential ranged between 18.5 mV-29.9 mV. The particle size was found to be increased with increase in the concentration and ratios of lipids. The ex vivo skin permeation studies on rat skin showed an appreciable increase in drug permeation in comparison to pure drug. The short term stability studies indicated no considerable change in drug content, loading and release profiles.