Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

Abstract

Formulation, Development and In Vitro Evaluation of Colon Targeted Drug Delivery System

Author(s): Anup D Ganore, Atishkumar S Mundada

Natural materials have been gaining lot of interest in the development of various drug delivery systems as they are readily available, cost effective, environment friendly, possibility of multitude of chemical modifications, biodegradable and biocompatible due to their natural origin. The present study was an attempt to evaluate the gum obtained from Delonix regia Seed Gum (DRSG) as a novel sustained release excipients in the development of tablet dosage form. The DRSG was evaluated for different physicochemical properties as per Indian Pharmacopoeia (IP) 2007. The water uptake was studied using, surface morphology and Fourier Transform Infrared (FTIR) spectroscopy study was carried out to find drug-polymer interaction. Tablets of diclofenac sodium, a model drug, were formulated using DRSG as matrix former by wet granulation method. Factorial design was employed considering amount of DRSG and core to coating ratio as independent variables while the percentage drug released and the lag time were the dependent variables. The developed tablets were assessed for thickness, diameter, weight variation, hardness, friability, content uniformity and in vitro drug release kinetics and were observed to have uniform appearance, average weight, drug content and adequate hardness. The inverse proportion was observed in the release rate and the DRSG concentration. It can be inferred from the present study that the desired drug release can be obtained by using DRSG as a novel sustained release excipients.


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