Fusion of pyrimidine moiety with different heterocycle scaffolds gives rise to a new class of hybrid heterocycles possessing improved activity. Heterocycles containing sulphur and nitrogen atoms in the core structure, shows number of pharmacologically and biologically active compounds. So, various fused pyrimidines like purines, pteridines, quinazolines, pyridopyrimidines, triazolopyrimidines, pyrazolopyrimidines, pyrimidoazepines, furopyrimidines and pyrrolopyrimidines were studied in the past decade and were found to possess remarkable pharmacological properties. The present review provides a broad view of the biological and medicinal properties expressed by compounds having fused Pyrimidine nucleus.
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