Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Glutamic acid analogues used as potent anticancer: A review

Author(s): Satyajit Dutta, Supratim Ray and K Nagarajan

Cancer is a class of diseases in which a group of cells display uncontrolled growth, invasin that intrudes upon and destroys adjacent tissues, and sometimes metastasis, or spreading to other locations in the body via lymph or blood. Cancer caused about 13% of all human deaths in 2007 (7.6 million). L-Glutamic acid plays an important role in the biosynthesis of purine and pyrimidine bases of DNA and RNA. The synthesis of L-glutamine is hindered in neoplastic cells due to lower reactivity of L-glutamine synthetase. L-glutamic acid γ-(4-hydroxyanilide) a growth regulatory substance isolated from mushroom Agaricus bisporous was found to inhibit B16 mouse melanoma cells in culture. The L-glutamic acid conjugated with paclitaxel is known to form a new anticancer called poly (LGA)-paclitaxel (PG-TXL) with superior antitumor activity. Glutamic acid and its derivatives will be more promising in its action against cancer with minimal side effects as they are endogenic in nature. Looking at the wide profile of activity, it has been proposed that though L-GA and glutamine were once considered nonessential for health, may now be considered as - ‘conditionally essential’ amino acids.


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