Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry


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Green and eco-friendly approach for the synthesis of pyrano[2,3-c]pyrazoles catalyzed by L-Proline in aqueous medium and their biological evaluation

Author(s): Anjna Bhatewara, Srinivasa Rao Jetti, Tanuja Kadre and Shubha Jain

6-Amino-5-cyano-4-aryl/heteroaryl-1,4-dihydropyrano[2,3-c]pyrazoles 5(a-h) were synthesized from arylidine malononitrile/arylidine ethylcyanoacetate 3(a-h) which were synthesized by the reaction of aromatic aldehydes and malononitrile, using L- proline as a catalyst in aqueous media. The reaction has the advantages of good yield, easy separation and of being environment friendly. The structures of newly synthesized compounds have been established by spectral analysis and evaluated for their anti-inflammatory, antibacterial, and antifungal activity


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