Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry


Green and efficient synthesis of pyranopyrazoles catalyzed by ammonium chloride in water

Author(s): Vijay P. Pagore, Balaji D. Rupnar, Sunil U. Tekale and Rajendra P. Pawar

We herein report a green and efficient ammonium chloride catalyzed four component condensation of aldehyde,
malononitrile, hydrazine hydrate and ethyl acetoacetate in aqueous medium to synthesize pyranopyrazoles. This
method follows the principle of green chemistry by using environmentally benign synthetic method along with use of
cost effective catalyst and green reaction medium.