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Green Rout of Synthesis of 3-(Ferfuraline-4-(5-P-tilyl-1,3,4 thiadiazole-2-ylimino)pentane-2-one imines and their Metal Complexes: A Study of Analytical and Microbial Activity | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Abstract

Green Rout of Synthesis of 3-(Ferfuraline-4-(5-P-tilyl-1,3,4 thiadiazole-2-ylimino)pentane-2-one imines and their Metal Complexes: A Study of Analytical and Microbial Activity

Author(s): M.B. Zade1*and S.N. Ibatte2

A new schiff base ligand, H2A1 and its Zn(II) complex were prepared and characterized by various analytical spectroscopic techniques.1:1 composition of metal ion and ligand was taken for complex formation. New schiff base ligand was characterized by NMR. Infrared spectra reveal that metal ion is coordinated in tridentate manner. The synthesized complex was also studied using UV-visible, TGA and XRD. TG analysis used for thermodynamic and kinetic study. The antimicrobial activity of the ligand andits complexes was examined against a variety of pathogenic bacteria and fungi including Escherichia coli, Staphylococcus aureus and Candida albicans. The data obtained revealed that the free ligand enhanced the antimicrobial activity compared to metal ion in the complexes. The high efficiencies are towards S. aureus, E. coli and C. albican.


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