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Green synthesis and antimicrobial evaluation ofpyrido[1,2-a]pyrimidine3-carbonitrile derivatives | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Green synthesis and antimicrobial evaluation ofpyrido[1,2-a]pyrimidine3-carbonitrile derivatives

Author(s): Shrikant V. Hese, Rahul D. Kamble, Pratima P. Mogle, Shital S. Kadam, Madhav J.Hebade, Ajay N. Ambhore and Bhaskar S. Dawane

A simple, green one pot three component approach for the synthesis of pyrido[1,2-a]pyrimidine-3-carbonitrile derivatives directly from corresponding 2-aminopyridines, substituted aldehydes, and malononitrile by using Bleaching earth clay (pH 12.5) and PEG-400 a recyclable catalytic system have been developed. All the synthesized compounds were characterized by spectral analysis. Furthermore, synthesized compounds were screened for their antimicrobial activity. Most of the synthesized compounds showantimicrobial activity.


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