A simple, green one pot three component approach for the synthesis of pyrido[1,2-a]pyrimidine-3-carbonitrile derivatives directly from corresponding 2-aminopyridines, substituted aldehydes, and malononitrile by using Bleaching earth clay (pH 12.5) and PEG-400 a recyclable catalytic system have been developed. All the synthesized compounds were characterized by spectral analysis. Furthermore, synthesized compounds were screened for their antimicrobial activity. Most of the synthesized compounds showantimicrobial activity.
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