Green synthesis of biginelli products of meldrum acid | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.


Green synthesis of biginelli products of meldrum acid

Author(s): Vijay V. Dabholkar, Mustaqeem Mohammed A., Navnath B. Shinde, Omprakash G. Yadav

A simple and efficient method has been devised for the synthesis of 3,3-dimethyl-7H,8H,10H-8,10-diaza-2,4-dioxa- 5,9-dioxo-7-(substituted) phenylbicyclo [4.4.0] dec-1(6)-ene (5) and 3,3-dimethyl-7H,8H,10H-8,10-diaza-2,4-dioxa- 5-oxo-9-thioxo-7-(substituted) phenylbicyclo [4.4.0] dec-1(6)-ene (6), by a one-pot three component cyclocondensation reaction of 1,3 dicarbonyl compound (Meldrum), aromatic aldehyde, and urea/thiourea using catalytic amount of fresh lemon juice in refluxing ethanol. Representative samples were screened for their antimicrobial activities against gram-negative bacteria and gram-positive bacteria using disc diffusion method. The structures of the products were confirmed by IR, 1H, 13C NMR and elemental analysis.


Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Google Scholar citation report
Citations : 25868

Der Pharma Chemica received 25868 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry