Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry


Green Synthesis of N-benzylidene-5-(styryl)-1,3,4-thiadiazol-2-amine and 4-(-2-(5-(-benzylideneamino)-1,3,4-thiadiazol-2-yl)vinyl)-2-methoxyphenol in Ionic Liquid

Author(s): Joshi Amol G, Jadhav SA, Shioorkar MG, Dhamnaskar RS, Pardeshi RK

An eco-friendly synthesis of N-benzylidene-5-(styryl)-1,3,4-thiadiazol-2-amine and 4-(-2-(5-(-benzylideneamino)-1,3,4-thiadiazol-2-yl)vinyl)-2- methoxyphenol starting from easily available reactant molecule. In the first step we synthesized substituted cinnamic acid and ferulic acid 3 from various types of aldehyde with malonic acid catalyzed by sodium acetate. In second step of reaction, multicomponent approach cyclization followed by Schiff base formation 6 a-j from prepared acids 3 a-j, thiosemicarbazide and aldehydes, solvent free catalyzed by ionic liquid [Et3N H2SO4] under conventional method.


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