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Green Synthesis of Pharmacologically Active Piperazine Substituted Schiff Bases and their Antimicrobial Activities | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Green Synthesis of Pharmacologically Active Piperazine Substituted Schiff Bases and their Antimicrobial Activities

Author(s): Krishnakant T Waghmode* and Bandoba T. Nikam

Green synthesis of piperazine substituted Schiff bases is described. Microwave-assisted synthesis not only reduced the reaction time drastically but also gave excellent yields. 2-naphthylpiperazine was converted to its ester followed by hydrazide. Hydrazide of 2-naphthyl piperazine was reacted with various substituted aromatic aldehydes under conventional heating and microwave irradiation method to get the final product. The synthesized compounds are characterized by FT-IR, 1H-NMR, and Mass spectral data.


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