Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

Abstract

Haematological and immunomodulatory evaluation of aqueous extract of Parthenium hysterophorus leaves on wistar rats

Author(s): Praveen Kumar Vemuri, Bhavana Talluri, Vasanthi Sirikonda, Tejaswi Padigala and Vijaya Lakshmi Bodiga

Parthenium hysterophorus has widely reported traditional uses which include its use for stimulation and purification of platelets as well as body defense. Experiments were carried out to assess the impact of Parthenium hysterophorus leaf extract on hematological parameters of wistar rats. The results revealed that the extract (10–100 mg/kg p.o.) produced no significant change in the packed cell volume, haemoglobin, red blood cell count, total leucocyte count, monocyte, basophil, eosinophil, bleeding time and clotting time. The dose of 100 mg/kg p.o. produced a significant (P<0.05) increase in neutrophil and decrease in lymphocyte. Platelet count was significantly (P<0.05) increased at the dose of 100 mg/kg p.o. The results did not support the traditional use of the plant leaf for stimulation of blood production. It however showed improvement of non-specific immune responses involving phagocytosis and inflammation.


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