Helianthus annuus, indigenous to Europe, possess an erect rough-hairy stem, reaching typical heights of 3 meters the common sunflower, is a large annual forb of the genus Helianthus grown as a crop for its edible oil and edible fruits seeds. The aim of this study is to overview its Pharmacological activity. This review article was carried out by searching studies in PubMed, Medline, , Web of Science, and IranMedex databases up to 2016.totally, of 78 found articles,40 articles(42 in vitro and 5 animal studies) were included. The search terms were “Helianthus annuus. ”, “therapeutic”, “pharmacological”, “Various studies have shown that Helianthus annuus. Process Salinity and sodicity stresses properties, Salinization stress properties, Anti-diabetes properties, Antioxidant properties , Herbicide properties ,Myocardial infarction properties, Allergy properties ,Skin barrier function ,Fatty acid patterns properties , Dermatitis properties. Helianthus annuus is shown to have lots of therapeutic activities causing its importance. Various combinations and numerous medicinal properties of this plantneed further and more studies about the other useful and unknown properties of this multipurpose plant.