The aim of the present work is to study the effect of Leucas aspera on CCl4 induced liver damage. The acute toxicity study of this plant material indicates that the plant material has no any toxic effect. Hepatotoxicity is produced by single intraperitoneal dose of CCl4 which alters the level of enzyme markers. The blood and tissue biochemical parameters were reported during animal trials. From these observations it is clear that this Leucas aspera has ability to regenerate liver cells The Leucas aspera plant material treatment in the form of aqueous slurry shows good matching of these parameters with normal control group. This plant material impairs normal liver functioning including distinct toxic changes in hepatocytes. Thus this plant may be used as good hepatoprotectant.