Historically because of safety of use, efficiency, cultural acceptability, and fewer side effects, herbal drugs have been frequently used in most communities. In light of acceptability of use and convenient accessibility to these plants among Iranians as well as possible side effects due to inappropriate use of them, this review article sought to investigate the attitudes toward use of herbal drugs and the used doses and methods of preparation and use of these plants among Iranians. In this review article, firstly 55 articles in Persian and English languages were examined and 30 articles were excluded from the study because of containing irrelevant content. After detailed analysis of 25 articles, 15 articles were selected and their findings were presented with regards to the purposes of this review article. Overall, 73.5% of women and 72% of men in Iran (totally 71.5% of Iranians) use herbal drugs, 82.9% of the people consider use of herbal drugs as effective, and 41.8% use them as tea. The sources of information are relatives and acquaintances for 37.5% of the Iran and Echium L., Valerianaceae officinalis L. Sisymbrium L. were the most frequently used herbal drugs. Herbal drugs are used mostly for gastrointestinal problems followed by respiratory problems, neurological problems, genitourinary problems and metabolic diseases. In view of high consumption of herbal drugs in Iran, potential side effects due to their excessive use, and current campaigns encouraging further use of them, it is necessary for experts, to offer necessary training on the preparation, dosage, maintenance, and side effects of herbal drugs to Iranians at various classes.