Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Heterogeneous Microencapsulated Copper (II) Acetylacetonate as Green Catalyst for Synthesis of Amidoalkyl Naphthol

Author(s): Bhikan J. Khairnar, Pravinsing S. Girase, Dhananjay V. Mane and Bhata R. Chaudhari

Microencapsulated-Cu(acac)2 [MC-Cu(acac)2] is found to be an efficient catalyst for the multicomponent condensation reaction of aromatic aldehyde, β-naphthol and amide to form the corresponding amidoalkyl naphthols in good yield. Moreover, the catalyst could be recycled for four times without the significant loss in yield and selectivity of the product. The remarkable features of this new one pot C-C and C-N bond forming reaction procedure are high conversations, operationally simple and eco-friendly and economically inexpensive method.


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