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Histochemical study of the response mechanisms of the nasal polyp tissue associated with the laser interstitial thermotherapy | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Abstract

Histochemical study of the response mechanisms of the nasal polyp tissue associated with the laser interstitial thermotherapy

Author(s): Alexander A. Blotsky, Ruslan A. Blotsky, Dmitry N. Lonshakov, Vladimir V. Chaika and Kirill S. Golokhvast

The paper presents the results of the histochemical study of the polyp tissue morphofunctional state associated with the laser interstitial (1 to 10 W) thermotherapy. It suggested the laser induces apoptosis of the polyp tissue cells via mitochondrial pathway, which is supported by the positive staining for caspase 3 and is dose-dependent. The study demonstrates that the inhibition of apoptosis by Bcl-xL occurs at the low laser intensity (1-5 W) and further (5-10 W) the process becomes unidirectional.

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