Ilaprazole, an anti-ulcer drug is used for the treatment for various acid related gastrointestinal (GI) disorders.During the laboratory optimization the formation of various impurities was observed. The impurities formed were monitored and their structures were tentatively assigned on the basis of their fragmentation pattern in LC-MS and other spectral data. Most of the impurities were synthesized and their assigned constitutions confirmed by co-injection in HPLC. We describe herein the formation, synthesis and characterization of these impurities.
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