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Identification and Synthesis of Impurities formed during Ilaprazole Preparation | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Abstract

Identification and Synthesis of Impurities formed during Ilaprazole Preparation

Author(s): T. Umasankara Sastry, K. Nageswararao and T. Appi Reddy

Ilaprazole, an anti-ulcer drug is used for the treatment for various acid related gastrointestinal (GI) disorders.During the laboratory optimization the formation of various impurities was observed. The impurities formed were monitored and their structures were tentatively assigned on the basis of their fragmentation pattern in LC-MS and other spectral data. Most of the impurities were synthesized and their assigned constitutions confirmed by co-injection in HPLC. We describe herein the formation, synthesis and characterization of these impurities.


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