GET THE APP

Identification and synthesis of impurity formed during Dabrafenib Mesylate preparation | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

Abstract

Identification and synthesis of impurity formed during Dabrafenib Mesylate preparation

Author(s): Madhuresh K. Sethi, Sanjay Mahajan, Bhairaiah Mara, Upendranath Veera, Anitha Nimmagadda and Purbita Chakraborty

Dabrafenib Mesylate (1), a typical anti neo plastic agent drug, is used for the treatment of skin cancer. During the laboratory optimization, formation of an unknown impurity at RRT ~ 0.94 was observed in the final Dabrafenib. Origin of the impurity was possible when chloro pyrimidine intermediate (15) was converted to Dabrafenib (1).In that, the aromatic fluoro group gets converted to amine which leads to the impurity formation (Phenyl amino Dabrafenib impurity (2)). This impurity was prepared and characterized by using spectroscopic techniques. Herein the formation, synthesis and characterization of this impurity is described. Our study will be of immense help to others in obtaining chemically pure Dabrafenib Mesylate.


PDF

Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Google Scholar citation report
Citations : 23677

Der Pharma Chemica received 23677 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry