Abstract

In-Situ Gel Systems for Ocular Therapeutics: Unveiling the Impact of Polymer Selection

Author(s): Aakanksha Sinha*, Vishal Das, Ramakant Yadav and S. J. Daharwal

A major problem in ocular therapeutics is the attainment of optimal drug concentration at the site of action, which is mainly due to precorneal loss resulting in only a small fraction of the drug being ocularly absorbed. Ensuring the use of in-situ gel-forming technologies, the effective dose can be changed by altering the medication's retention duration in the eye. The "in situ gel" system has become one of the top cutting-edge drug delivery systems; its special "sol to gel" transition feature helps with the controlled and continuous release of medications. An in-situ gelling system is a formulation that, before it enters the body, stays in the liquid form but that, when subjected to specific physiological circumstances, transforms into gel form. Various polymers are subjected to in situ gel formation and could be employed for a variety of drug administration routes. In today's world, the in-situ gelling system has a variety of uses and benefits. This paper focuses on an overview of in situ gels, their mechanisms, the various polymers utilized and their applications in situ gel, novel drug delivery system, polymers.

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