In this study, the antioxidant efficacy of various extracts of an ethnobotanically important plant, Pogostemon quadrifolius (Benth.) belonging to Lamiaceae was examined by various antioxidant assays, including total antioxidant (Phosphomolybdenum assay), 1,1 diphenyl–2–picrylhydrazyl (DPPH) and Ferric Reducing Antioxidant Power (FRAP) assay. The various antioxidant activities were compared to standard antioxidant ascorbic acid. Most of the extracts showed strong antioxidant activities in all the tested methods. Methanolic extracts of leaves and flowers of P. quadrifolius showed high DPPH antioxidant activity followed by acetone extracts. Moreover floral extracts are more efficient DPPH radical scavengers than leaf extracts. Among the leaf extracts acetone extract showed maximum reducing power ability (FRAP) and among flower extracts petroleum ether extract showed maximum reducing power. The total antioxidant capacity (Phosphomolybdenum assay) results are also provided. The study indicates that P. quadrifolius may be a potential source of natural antioxidants and can be used for therapeutic purposes.