Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

Abstract

In vitro assays of the antioxidant activities of ferrocene derivatives bearing amine, amide or hydrazine groups

Author(s): Abdelhamid Khelef and Touhami Lanez

The aim of this work was to synthesise a series of three ferrocene derivatives bearing either amine, amide or hydrazine groups and to evaluate their in vitro antioxidant activities. Spectrophotometrical and electrochemical techniques were used to quantify the total antioxidant activities, the former was carried out using 1,1-diphenyl-2- picrylhydrazyl and phosphomolybdenum reagents, the latter was based on measuring the oxidation peak current of superoxide anion radical electrochemically generated by reduction of commercial molecular oxygen in DMSO. The ferrocenic derivative N’-ferrocenylmethyl-N’-phenylbenzohydrazide shows the highest DPPH and  .radicals scavenging activities (0.1 ± 0.00245) and (0.92 ± 0.04 mg/ml) respectively which was significantly closer to that of standard antioxidant ascorbic acid. The results of both spectrophotometrical and electrochemical tests indicate that the activity depends strongly upon the presence of a nitrogen atom in the molecule but is improved by the influence of the hydrazine function. In addition spectrophotometrical tests of N-(Ferrocenylmethyl)-2-nitrobenzenamine does not give any activity due to its deep purple colour, however the antioxidant activity of this derivative was easily measured using electrochemical tests.


PDF

FIND ARTICLES
SCImago Journal & Country Rank
 
Erkek öyle sert ve acımaz sikiyor ki bayan çaresiz bir şekilde tırtıl misali sikiş yataktan aşağı doğru kayıyor fakat hem adam hemde kadın aşırı mobil porno derecede zevk alıyorlar Uzun zamandır karısı ile ilgili planları olan türk porno adam onu başkaları sikerken hayal ediyor bu durumu karısından sikiş izle gizliyordu fakat bir gün adamın moralinin bozuk olduğunu anlayan karısı sikiş ona ne olduğunu sordu ve adamda ona her şeyi anlatmıştı karısı bu porno resim durumdan Büyük zenci yarağı sevenler için özel olarak eklenmiş videomuz türk porno kalın ve damarlı zenci siki arayıp bulamayanlar için özel olarak sikiş izle yayınlanmıştır filmde ise sarışın zengin sürtük büyük mobil sikiş kalın damarlı alet sevdiğini bir çok kez dile getirmiş