In vitro hepatoprotective activity of Azima tetracantha leaf extract and silver nanoparticle in hepatocytes | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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In vitro hepatoprotective activity of Azima tetracantha leaf extract and silver nanoparticle in hepatocytes

Author(s): E. Prakash 1 , T. Jeyadoss 1# and S. Velavan 2

Hepatocytes have become valuable tools to evaluate the possible protective effect of drugs in the rece nt past. The techniques for high yield hepatocytes are made it a s useful model. The study was aimed to synthesize t he nanoparticles and evaluate the In vitro hepatoprote ctive activity of Azima tetracantha leaf extract and Silver nanoparticle (100, 200 and 300 μ g/ml) through CCl 4 induced toxicity in hepatocytes. Silver nanopart icles were effectively synthesized from aqueous leaf extract o f Azima tetracantha under pH and temperature-depe ndent condition. 1mM Silver nitrate. All the variables te sted as Protein, ALP, GOT and GPT recorded a signif icant Alteration observed in CCl 4 exposed rats. However treatment with Silver nanopar ticle restored the level to near normal was observed than Azima tetracantha leaf treated groups. Nanoparticles were characterized us ing UV–Vis absorption spectroscopy and SEM analysis showed the average particle size of 100nm as well as revealed their cubic structure. The potential hepatoprotective act ivity of Silver nanoparticleis due to radical scave nging property of Silver ion.


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