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Indion 190 Resin Catalyzed Environmentally Benign Protocol for Synthesis of an Anticancer Drug Enzalutamide | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Indion 190 Resin Catalyzed Environmentally Benign Protocol for Synthesis of an Anticancer Drug Enzalutamide

Author(s): Sampat Yewale*, YS Malghe

An environmentally benign and economically viable protocol has been developed for the synthesis of the anticancer drug Enzalutamide using Indion 190 resin. Ambient condition, short reaction time, simple work-up procedure, high yield, easily available and reusable heterogeneous Indion 190 catalyst, are some of the striking features of the present method. Enzalutamide is known as 4-{3-[4-cyano-3-(trif1uoromethy1) pheny1]-5,5-dimethy1-4-oxo-2-su1fanylide-neimidazolidin-1-yl}-2-f1uoro-N-methy1benzamide. Enzalutamide is an androgen receptor inhibitor that acts on different steps in the androgen receptor signaling pathway. Enzalutamide has been shown to competitively inhibit androgen binding to androgen receptors and inhibit androgen receptor nuclear translocation and interaction with DNA


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