GET THE APP

Inhibitory activity of Euphorbia hirta (Tawa- tawa) extracts against Mycobacterium tuberculosis and other non mycobacterial pathogens | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

Abstract

Inhibitory activity of Euphorbia hirta (Tawa- tawa) extracts against Mycobacterium tuberculosis and other non mycobacterial pathogens

Author(s): Thirunavukkarasu Rajasekar, Sivaraj Anbarasu, Radha krishnan Manikkam, Jerrine Joseph* and Vanaja Kumar

Methanol, ethyl acetate and n-hexane extracts from the leaves of Euphorbia hirta were screened against non- mycobacterial pathogens and Mycobacterium tuberculo sis H 37 Rv using agar well diffusion and Luciferase Reporte r Phage (LRP) assay, respectively. Methanol extract o f Euphorbia hirta showed 10-15 mm inhibition against B. subtilis, E. coli, and V. cholerae at 100μ g/ml wher eas no activity was observed against S. aureus and E. faecalis. The ethyl acetate extract showed activity only B. s ubtilis (12mm) and E. faecalis (10mm) while n- hexa ne extract showed no activity. In LRP assay, the ethyl acetate extract showed better activity with maximum of 64. 73% reduction in RLU against M. tuberculosis H 37 Rv compared to methanol and n-hexane extracts. Furt her bioassay guided fractionation is in progress for the isolati on, characterization and identification of active p rinciple from Euphorbia hirta leaves.


PDF

Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Google Scholar citation report
Citations : 15261

Der Pharma Chemica received 15261 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry