Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Inhibitory effects of Blackstonia grandiflora extracts on the formation of advanced glycation end products (AGEs)

Author(s): Fatima Zohra Belfadela, Kamel Medjroubia, Salah Akkala, Séverine Derbréb and Elisabeth Seguinc

Glycation, the nonenzymatic reaction of reducing sugars with amino groups, is increased in hyperglycemic physiological environments, leading to an acceleration of the formation of advanced glycation end products (AGEs). The AGEs are associated with many pathogenic disorders such as Alzheimer’s disease, pathogenesis of diabetes, and atherosclerosis. They are also responsible for aging and tissue damage. In this study, the antiglycation activity of the extracts Blackstonia grandiflora (Viv.) was evaluated in the bovine serum albumin (BSA)/ribose system and the potency of these extracts was compared with the standard antiglycation agent aminoguanidine. The results showed that EtOAc extract had a significant inhibitory effect on the formation of advanced glycation end products (AGEs).


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