GET THE APP

Innovative synthesis and anti-microbial activity study of innovative Mannich bases containing 2-phenoxy-1,3,2-dioxa phospholanes and indole systems | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

Abstract

Innovative synthesis and anti-microbial activity study of innovative Mannich bases containing 2-phenoxy-1,3,2-dioxa phospholanes and indole systems

Author(s): Subba Narayana Kanchana, Venkataramudu Burra, L. K. Ravindra Nath

In the present study, synthesis, characterization, antimicrobial activity on some novel pyrazolone derivatives has been taken up. Reaction of (4Z)-2-{4-[(15Z)-4-(2-phenylhydrazono)-4,5-dihydro-3-methyl-5-oxopyrazol-1-yl] phenylamino}-N'-(2-oxoindolin-3-ylidene) acetohydrazide and acetophenones were refluxed in methanol containing a catalytic amount of glacial acetic acid for 4 hours furnished the corresponding (19Z)-2-{4-[(4E)-4-(2-substituted aryl hydrazono) -4,5 -dihydro-3 –methyl -5-oxopyrazol -1-yl] phenylamino}-N'-(1-phenylethylidene) acetohydrazide step-1 product in excellent yields. Step-I products and excessive acetic anhydride was refluxed to afforded (4E)-4- (2-substituted aryl hydrazono)-1-{4-[(4-acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-oxadiazol-2-yl) aminomethyl] phenyl}-3-methyl-1H-pyrazol-5(4H)-one step-II product. The structural assignments to compounds Step-I product and Step-II product were based on their elemental analysis and spectral (IR, 1HNMR and MS) data. The antibacterial activity of synthesized compound was studied by the disc diffusion method against pathogenic bacteria and fungi.


PDF

Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Google Scholar citation report
Citations : 25868

Der Pharma Chemica received 25868 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry