The Notch signaling pathway is an evolutionarily conserved cell signaling system, which regulates cell proliferation, cell fate, differentiation, and cell death in all metazoans. The notch receptor is a single-pass transmembrane receptor protein which contains four Notch homologues, NOTCH1, NOTCH2, NOTCH3, and NOTCH4 identified in the human genome and aberrant Notch function has been associated with a number of human diseases including Cancer and it also plays a key role in modulating cell fate decisions throughout the development of invertebrate and vertebrate species. The focus of this article primarily depends on the literature evidence that many phytochemicals i.e., chief chemical moieties of various plants show a great significance in the regulation of this notch signaling pathway. Some of these phytochemicals include Resveratrol, Curcumin, Genistein, Sulforaphane, Isooquercitinin, Koenimbin, Withaferin. So the chemical structures of these phytochemicals were taken and in-silico molecular docking was done with the notch receptor to show the Energy binding values. With these values it can be concluded that these phytochemicals can be used as biotherapeutics in regulating the notch thus making alterations in the Notch signaling system and achieving an effective contrivance in treating diseases right from embryogenetic disorders to cancer stem cells. Thus this regulation of the notch signaling pathway will serve to be a breakthrough in the pharmaceutical world using phytochemicals as biotherapeutics.