Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry


Interaction of Schiff Base Derived from 4-chloro-5-sulfamoyl-2’,6’-salicyloxylidide with Ni(II), Co(II) and Cu(II)

Author(s): Suparna Ghosh, Shweta Sharma, Ruchi Dubey Sharma, Anita K, Suman Malik, Bharti Jain

A new unsymmetrical bidentate Schiff base was synthesized using 4-chloro-5-sulfamoyl-2’,6’-salicyloxylidide (xipamide) and salicylaldehyde. The Ni(II), Co(II) and Cu(II) complexes of this Schiff base of ML2 type have been synthesized and characterized by elemental analysis, conductivity, magnetic measurements, IR and electronic spectra studies. The conductivity data of the complexes suggests their non-electrolytic nature. The antibacterial activities of the ligand and its complexes are also studied. The antibacterial experiments indicate that the ligand and its complexes possess antibacterial activity against Escherichia coli and Bacillus subtilis and that the complexes have higher activity than that of the Schiff base.