Ionic liquid is an efficient catalyst for Knoevenagel condensation under grinding method | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.


Ionic liquid is an efficient catalyst for Knoevenagel condensation under grinding method

Author(s): Kiran F. Shelkea and Ravi E. Khadse

A simple, green and environmentally benign route has been developed for the Knoevenagel condensation of 4-oxo- (4H)-1-benzopyran-3-carbaldehydes and 2-chloroquinoline-3-carbaldehyde with various active methylene compounds viz. malononitrile, ethylcyanoacetate, cyanoacetic acid, cyanoacetamide and Meldrum’s acid were carried out in the presence of catalytic amount of basic ionic liquid 1-benzyl-3-methylimidazolium hydroxide ([bnmim]OH) by grinding method. The remarkable advantages of the present method are mild reaction conditions, short reaction time, excellent yields and green aspects by avoiding toxic catalyst and hazardous solvent. Additionally, the ionic liquid was successfully reused for four cycles without significant loss of activity.


Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Recommended Conferences

14th World Congress on Chemistry
Barcelona, Spain

19th European Organic Chemistry Congress
London, UK
Google Scholar citation report
Citations : 11575

Der Pharma Chemica received 11575 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry