Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

Abstract

IR-spectroscopy research into the structure of products of interaction between metronidazole and metal salts

Author(s): Artem V. Myhal, Olga S. Golovchenko, Tetiana V. Krutskikh, Svitlana M. Gubar and Victoriya A. Georgiyants

The studying of the drugs interaction is a pressing problem in practical medicine and pharmacy that requires additional investigation of the nature of its influence on the biological activity of pharmacological substances and on the organism of a patient. To study the nature of the interaction we have synthesized compounds that are products of interactions of metronidazole with metal salts, which are components of drugs. Investigation of structures of the obtained compounds was carried out by IR spectrometry using infrared spectrometer with Fourier transformation Tensor 27 «Bruker» (Germany). The changes in the infrared absorption spectra indicate changes in the structure of metronidazole in the cases of interaction of metal cations. It confirms obtaining of new compounds. During the research it was established that metronidazole behaves like a bidentate ligand. Specifically, for the samples of Metronidazole-Mg, Metronidazole-Al, Metronidazole-Fe2+ and Metronidazole-Bi it was established that the metronidazole is associated with metal cation via the nitrogen atom, which is located in the third position of the imidazole cycle, and through the oxygen atom of the hydroxy group. The results, obtained in the study of the Metronidazole-Ca and Metronidazole-Fe3+ samples, indicates a slightly different nature of the interaction that needs further study.


PDF

FIND ARTICLES
SCImago Journal & Country Rank
 
Erkek öyle sert ve acımaz sikiyor ki bayan çaresiz bir şekilde tırtıl misali sikiş yataktan aşağı doğru kayıyor fakat hem adam hemde kadın aşırı mobil porno derecede zevk alıyorlar Uzun zamandır karısı ile ilgili planları olan türk porno adam onu başkaları sikerken hayal ediyor bu durumu karısından sikiş izle gizliyordu fakat bir gün adamın moralinin bozuk olduğunu anlayan karısı sikiş ona ne olduğunu sordu ve adamda ona her şeyi anlatmıştı karısı bu porno resim durumdan Büyük zenci yarağı sevenler için özel olarak eklenmiş videomuz türk porno kalın ve damarlı zenci siki arayıp bulamayanlar için özel olarak sikiş izle yayınlanmıştır filmde ise sarışın zengin sürtük büyük mobil sikiş kalın damarlı alet sevdiğini bir çok kez dile getirmiş