Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

Abstract

Isolation of Chemical Compounds from Root of Artocarpus camansi and Antidiabetic Activity Test

Author(s): Rosnani Nasution, Sri Endang Wahyuni, Mustanir, Bastian Arifin, Marianne

The antidiabetic test of crude extract of n-hexane, group of fraction A, group of fraction B, group of fraction C, group of fraction D and isolate of C43 from root skin of Kulu (A. camansi), it is known that group of fraction A can lower blood sugar of mice is the biggest, that is at min 60 th , followed by crude extract of n-hexane, group of fraction B, group of fraction C, group of fraction D and isolate C43. The C4 3 isolate the largest of which decreased blood glucose in the 30 th min, but in the 90 th min raised blood glucose in mice. The fraction group of A had lower mean blood glucose levels and significantly different from the positive control with 95% confidence level (P<0.05) at min 120 th . The result of the separation of fraction group guided by activity anti-diabetes obtained isolate C43, The isolate of C43 after they were characterized by 1 H-NMR, 13 C-NMR, FT-IR and MS (GC-MS), were suggested as lupeol acetate.


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