Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Kinetic spectrophotometric method for the estimation of cefixime in pharmaceutical formulations

Author(s): Ashok Kumar, Lalit Kishore, Anroop Nair, Navpreet Kaur

The objective of the current study was to develop a simple, sensitive kinetic spectrophotometric method based on the oxidation of Cefixime using potassium permanganate in alkaline medium. The rate of change of absorbance was measured at 598 nm. The initial rate method and fixed time method (at 4 min) are utilised to construct calibration graphs for calculating the concentration of the drug. The results were validated through inter day and intraday precision assays according to the ICH guidelines and also through recovery studies. Statistical comparison of the proposed methods with that of reference method shows excellent agreement and indicates no significant difference in their accuracy and precision.


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