Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry


Kinetics and Thermodynamics of Oxidation of 3,4,5-trimethoxy Aniline by Tetrabutylammonium Bromochromate in Acetic Acid-water Medium

Author(s): Shaik Jabir, Sheik Mansoor S

Anilines are widely used in the manufacture of dyes, medicinal, plastics and perfumes. Anilines are readily oxidized to give products depending on reaction conditions. Conversion of anilines to azobenzene is important in organic synthesis. The kinetics of oxidation of 3,4,5-trimethoxy aniline (3,4,5-TMA) by Tetrabutyl Ammonium Bromochromate (TBABC) in the presence of perchloric acid in aqueous acetic acid medium has been described. The reaction is first order with respect to [TBABC], [3,4,5-TMA] and [H+]. The reaction rate has been determined at different temperatures and activation parameters calculated.