Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Lacatums of thiazol-4-ones

Author(s): Vijay V Dabholkar, Sagar D. Shah and Viral M. Dave

4H-2-(substituted-benzylidino)-hydrazino-4-phenyl-5-oxo-1,3-thiazole were prepared by reacting Ethyl-2-bromo-2- phenylethanoate and Schiff’s base of thiosemicarbazide. The product was obtained in 10 mins in the presence of acohol as a solvent. The obtained product was further converted into β-lactum by reacting with chloroacetylchloride. Structure of thiazoles and β-lactum was confirmed by spectral techniques


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