GET THE APP

LcK Inhibitors and its analogues: A Review | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

Abstract

LcK Inhibitors and its analogues: A Review

Author(s): Renuka Khatik and AK Pathak

T-cells play an important role in the pathogenesis of many diseases. These include diseases with large commercial markets and also with significant unmet medical needs, such as rheumatoid arthritis and asthma in addition to those with smaller markets such as organ transplantation. Lck, one of eight members of the Src-family of tyrosine kinases, is activated following T cell stimulation and is required for T cell proliferation and IL-2 production. Inhibition of Lck has been a target to prevent lymphocyte activation and acute rejection. In this review we amass different functions and different moieties which act as an lck inhibitor for the treatment of different diseases. In addition we provide an analysis of the properties of these compounds that account for the specificity required for the inhibition of one of eleven highly similar kinases.


PDF

Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Google Scholar citation report
Citations : 23677

Der Pharma Chemica received 23677 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry