The hindrance effect for corrosion of some drugs on metal in 0.5M hydrochloric acid was done by chemical (WL) and electrochemical(EIS, EFM, tafel polarization) techniques. Themorphology of surface utilized by EDX and electron scanning microscopy (SEM) method. From the data obtain the efficiency inhibition rise with higher the concentration inhibitor but lowering by increment of temperature. Potentiodynamic polarization for compounds given both the anodic and cathodic processes and play as mixed-type. The isotherm of adsorption of drug on metal follow the Temkin adsorption. The temperature effect on inhibition corrosion has been doneand thermodynamic activation.