Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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L-Proline catalyzed one pot synthesis of novel 1,4-dihydro pyridine derivatives

Author(s): AV Hanumantha Rao, A Tejeswara Rao, V Lakshman Rao and A Jaya Shree

Multi component, one pot synthesis of diethyl/ dimethyl 4-(2-butyl-4-chloro-1H-imdazol-5-yl)-2,6-dimethyl-1,4- dihydro pyridine-3,5-dicarboxylayte derivatives 3(a–f) form the condensation of N-alkyl-2-butyl-4-chloro-1Himidazole- 5-carbaldehydes 1(a–c), methyl/ethyl acetoacetate (2), ammonium carbonate has been described using Lproline as a environmentally benign catalyst. L–proline catalyzed reaction provides a green and inexpensive preparation method for synthesis of above compounds.


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