Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Maleic acid as a versatile catalyst for one pot synthesis of 3,4-dihydropyrimidin-2-(1H)-ones and their thione analogues

Author(s): Aniket P. Sarkate,* Mohan R. Jadhav, Mujahed H. S. H. Ansari and Mrudula P. Waghmare

Maleic acid catalyzed 3,4-Dihydropyrimidin-2-(1H)-ones and their thione analogues have been synthesized by condensation of aromatic aldehydes, β-dicarbonyl compound and urea or thiourea in the presence of alcohol-water (2:1; v/v) under mild reaction conditions. The yields obtained were excellent. The use of very cheap non-hazardous catalyst, environmentally benign solvent and easy work-up are the perspectives advantageous aspects of the present method.


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