Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

Abstract

Method Development and Validation for the Quantitative Estimation of Rimonabant in pharmaceutical preparation by RP- HPLC

Author(s): Shailendra Bindaiya, Ameeta ArgaL

A Simple, selective, rapid, precise and economical reverse phase HPLC method has been developed and validated for the Quantitative Estimation of Rimonabant in pharmaceutical preparation. Isocratic separation was accomplished using C18 column (250 mn x 4.6 mm, 5 μm particle size) with mobile phase consisting of acetonitrile: 0.1% Formic acid (90:10, v/v), flow rate was 1.0 ml/min. and the detection wavelength was 268 nm. The proposed method has permitted the quantification of Rimonabant in the linearity range of 10- 50μg/ml .The column was maintained at ambient temperature and analytical run time of approximately 10 min and it was eluting at approximately 6.4 min.The percentage recovery was found to be in between 96.30 to 99.12 and the % RSD of system and method precision was found to be 1.27. The percentage amount of marketed commercial brand of Rimonabant was found to be 99.63. The method was validated for linearity, accuracy, precision, specificity, Robustness, Ruggedness, solution stability, the assay may be applied to a routine analysis in industries.


PDF

FIND ARTICLES
SCImago Journal & Country Rank
 
Erkek öyle sert ve acımaz sikiyor ki bayan çaresiz bir şekilde tırtıl misali sikiş yataktan aşağı doğru kayıyor fakat hem adam hemde kadın aşırı mobil porno derecede zevk alıyorlar Uzun zamandır karısı ile ilgili planları olan türk porno adam onu başkaları sikerken hayal ediyor bu durumu karısından sikiş izle gizliyordu fakat bir gün adamın moralinin bozuk olduğunu anlayan karısı sikiş ona ne olduğunu sordu ve adamda ona her şeyi anlatmıştı karısı bu porno resim durumdan Büyük zenci yarağı sevenler için özel olarak eklenmiş videomuz türk porno kalın ve damarlı zenci siki arayıp bulamayanlar için özel olarak sikiş izle yayınlanmıştır filmde ise sarışın zengin sürtük büyük mobil sikiş kalın damarlı alet sevdiğini bir çok kez dile getirmiş